Asymmetric Preparation of prim-, sec-, and tert-Amines Employing Selected Biocatalysts

نویسندگان

  • Wolfgang Kroutil
  • Eva-Maria Fischereder
  • Christine S. Fuchs
  • Horst Lechner
  • Francesco G. Mutti
  • Desiree Pressnitz
  • Aashrita Rajagopalan
  • Johann H. Sattler
  • Robert C. Simon
  • Elina Siirola
چکیده

This account focuses on the application of ω-transaminases, lyases, and oxidases for the preparation of amines considering mainly work from our own lab. Examples are given to access α-chiral primary amines from the corresponding ketones as well as terminal amines from primary alcohols via a two-step biocascade. 2,6-Disubstituted piperidines, as examples for secondary amines, are prepared by biocatalytical regioselective asymmetric monoamination of designated diketones followed by spontaneous ring closure and a subsequent diastereoselective reduction step. Optically pure tert-amines such as berbines and N-methyl benzylisoquinolines are obtained by kinetic resolution via an enantioselective aerobic oxidative C-C bond formation.

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عنوان ژورنال:

دوره 17  شماره 

صفحات  -

تاریخ انتشار 2013